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J&J Vaccine FAQs: Does the vector DNA combine with our DNA? What happens to the DNA? Could the vector go latent?

J&J Vaccine FAQs: Does the vector DNA combine with our DNA? What happens to the DNA? Could the vector go latent? published on

References:
1. Lee CS, Bishop ES, Zhang R, Yu X, Farina EM, Yan S et al. Adenovirus-mediated gene delivery: potential applications for gene and cell-based therapies in the new era of personalized medicine. Genes Dis. (2017) 4:43–63
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5609467

2. Custers J, Kim D, Leyssen M, et al. Vaccines based on replication incompetent Ad26 viral vectors: standardized template with key considerations for a risk/benefit assessment. Vaccine 2020 October 2 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7532807/

3. Sompayrac LM. How the immune system works. Malden, MA: Blackwell; 2019